Scientists understand that a mutation - or alteration - in a specific gene's DNA may additionally moreover contribute to a sure disorder. but, it can be very difficult to expand a check to discover these mutations, because most big genes have many areas wherein mutations can arise. as an example, researchers believe that mutations in the genes BRCA1 and BRCA2 cause as many as 60 percentage of all cases of hereditary breast and ovarian cancers. However there isn't one precise mutation responsible for all of those instances. Researchers have already found over 800 one-of-a-kind mutations in BRCA1 on my own. The DNA microarray is a tool used to determine whether or not or no longer the  DNA from a selected person incorporates a mutation in genes like BRCA1 and BRCA2. The chip consists of a small glass plate encased in plastic. a few companies manufacture microarrays the usage of techniques similar to the ones used to make laptop microchips. on the floor, every chip contains masses of brief, synthetic, unmarried-stranded DNA sequences, which collectively add as much because the everyday gene in question, and to versions (mutations) of that gene which have been determined within the human populace. Microarrays also can be used to have a look at the quantity to which certain genes are have become on or off in cells and tissues. In this case, instead of keeping apart DNA from the samples, RNA (it is a transcript of the DNA) is remoted and measured.

To increase the visibility and ease of use of open access scientific and scholarly journals top online publishing journals are indexed in different indexing and archiving services. Indexing provides easy access of the article online. The top online publishing journals publish articles which are cited as references by many authors in their work. Citations are important for a journal to get impact factor. Impact factor is a measure reflecting the average number of citations to recent articles published in the journal. The impact of the journal is influenced by impact factor, the journals with high impact factor are considered more important than those with lower ones. Indexing provides easy access of the article online. The international journals are among the best open access journals in the world, set out to publish the most comprehensive, relevant and reliable information based on the current research and development on a variety of subjects. This information can be published in our peer reviewed journal with impact factors and are calculated using citations not only from research articles but also review articles (which tend to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports. The inclusion of these publications provides the opportunity for editors and publishers to manipulate the ratio used to calculate the impact factor and try to increase their number rapidly. Impact factor plays a major role for the particular journal.