The definition of a work-up is a complete medical examination including a medical history, physical exam, lab tests, x-rays and analysis, or an unwanted mark on a printed page caused by improperly positioned spacing type or bars. An example of a work-up is a thorough physical.The definition of a work-up is a complete medical examination including a medical history, physical exam, lab tests, x-rays and analysis, or an unwanted mark on a printed page caused by improperly positioned spacing type or bars. An example of a work-up is a thorough physical.