The well water is used for domestic purposes including drinking. In many cases the wells are situated very close to pit latrines increasing the risk of contamination. This study attempted to assess the microbial and nutrients contamination in domestic well during dry and rainy season. Said A H Vuai; Microbial and Nutrient Contamination of Domestic Well in Urban-West Region, Zanzibar, Tanzania Biosafety Journal of PrimeOA Publications is the leading and top Journals in the scientific community of Open Access journals. PrimeOA Publications through its Open Access Initiative is committed to make genuine and reliable contributions to the scientific community. It follows an Open Access publication model that enables the dissemination of research articles to the global community free of cost. It has more than 700+ peer-reviewed journals and organizes more than 3000+ International Scientific Conferences. We have more than 50,000+ editorial board members and more than 15 million readers. Biosafety: open access is one among the top journals which publish novel work in the form of research or review articles related to biological safety procedures. This journal publishes articles after being reviewed by 2 experts of the concerned field. PrimeOA Publications International is an online directory that indexes and provides access to quality open access, Top journals in-order to collaborate and tie up with the scientific communities of other Open Access journal publishers. Biosafety is a forum for Scientists from all over the world to exchange ideas and to propagate the scientific knowledge. The Bulletin of Environmental Contamination and Toxicology provides rapid publication of peer-reviewed articles describing significant advances and discoveries in the fields of air, soil, water, and food contamination and pollution as well as articles on methodology and other disciplines concerned with the introduction, presence and effects of toxicants in the total environment. With its high standards of scientific quality and clarity, the Bulletin provides a meeting ground for research workers who daily encounter problems related to the contamination of our environment and who welcome opportunities to share in new discoveries as soon as they are made