Liver metastasis is that the commonest sort of distant metastasis in colorectal cancer. Hepatic metastatic disease from colorectal cancer (CRC) may be a significant clinical problem. The liver is that the dominant metastatic site for patients with CRC, and although two-thirds of affected patients have extrahepatic spread, some have disease that's isolated to the liver. Tumour biology is increasingly recognized as an important prognostic factor; hence molecular profiling has a growing role in risk stratification and management planning. Surgical resection is the only treatment modality for curative intent. The recent debate about offering liver transplantation to highly selected patients’ needs validation from large clinical trials. Approximately, 30–50% of those patients will present with liver metastasis at the time of diagnosis or will develop metastasis later. The types of symptoms depend upon the dimensions of the cancer and where in your body it's spread. Some people with carcinoma that has spread to the liver do not have any symptoms. Blood in the stool, Pain in the right side of your belly, Swelling in your belly, A tired, sick feeling, Weight loss. Surgical and ablative treatments of other sites of disease including lung, lymph nodes, peritoneum, bone, and brain.