Ageing has a negative impact on a variety of high-level cognitive functions, including working recollection (WM)1. WM plays a crucial role in goal-directed demeanor, by performing the short-term maintenance and phrenic manipulation of information compulsory for accomplishing our perpetual tasks2,3. The age-cognate impairment in WM may arise in the forms of capacity-minimization and decline in the filtering of germane information4, diminution of the maintained representations’ resolution, and the incrementation in variability with which the memoranda are recollected, especially under high cognitive load5,6. Importantly, WM relies on the neural interactions within a network of distributed cortical and subcortical encephalon regions, including the dopamine neurotransmission mediated computations within the fronto-striatal circuitry (for a review see7). Consequently, it is plausible to postulate that age-dependent deterioration of the dopaminergic system1,8,9 might play a consequential role in the decline of WM performance in senescent.

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