The examination will cover all aspects of clinical cytogenetic, including prenatal and postnatal diagnosis, cancer cytogenetic (leukemia and solid tumour) molecular cytogenetic and chromosome breakage syndromes. Candidates should have a sound understanding of human genetics and genomics, and a basic knowledge of molecular genetics. An understanding of the role of related disciplines such as biochemistry, immunology, microbiology, hematology and histopathology within the patient pathway is required. A detailed and up-to-date knowledge of the following subjects is required: the structure and function of the human genome, the structure and function of human chromosomes, the clinical relevance of chromosome abnormalities – both constitutional and acquired, the practical techniques used for the preparation and analysis of chromosome preparations and molecular cytogenetic including FISH and microarray CGH.A general knowledge of the following areas is required: a general knowledge of the sciences basic to genetics with particular reference to human genetics, Mendelian inheritance, disease gene identification, the fundamental principles of cell biology, aspects of epidemiology, statistics, common genetic disorders and the principles of genomic technology.