Evolutionary geneticists like Theodosius Dobzhansky centered on chromosomal inversions, not handiest as polymorphisms that various inside species, however additionally as capacity drivers of divergence and speciation (Dobzhansky 1970). However, the improvement of molecular biology shifted the focus of many evolutionary biologists to series-primarily based variation, and hobby within the function of chromosomal change in evolutionary procedures fell in most cases out of vogue.At the equal time as interest in chromosomes become waning in evolutionary biology, the molecular biology revolution enabled scientists to investigate the molecular mechanisms that underlie chromosome structure and feature. Thus, a big frame of labor over the previous couple of a long time has brought about an in depth molecular information of chromosomes and their component elements which include chromatin, centromeres, and telomeres, in addition to how chromosomes recombine with every different and are transmitted via meiosis.This molecular understanding of chromosome structure is now becoming greater applicable for evolutionary biologists, as advances in genome sequencing have found out extra variant in chromosome shape that can't be determined by means of cytogenetic methods. These findings have reminded evolutionary biologists that version in chromosome shape is huge and might have evolutionary results. Thus, there has been a resurgence of interest in traditional questions: How do chromosomal differences evolve between populations or species? What evolutionary forces force differences in chromosome