cell signaling is the system that coordinates the cell communications and cellular activities. The vicissitudes occur in cell to environmental conditions and their replication towards the reaction. Cell signaling is of two types they are intracellular signaling and extracellular signaling, if the signaling takes place within the cell is called intracellular signaling, if it occurs outside is called extracellular signaling. High-impact journals are those considered to be highly influential in their respective fields. The impact factor of journal provides quantitative assessment implement for grading, evaluating, sorting and comparing journals of homogeneous kind. It reflects the average number of citations to recent articles published in science and gregarious science journals in a particular year or period, and is frequently utilized as a proxy for the relative consequentiality of a journal within its field. It is first devised by Eugene Garfield, the progenitor of the Institute for Scientific Information. The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the antecedent two years.