Cell separation is the process of removing one cell population from another within a biological sample, such as blood or tissue. Cell biology is complex, given the multitude of variables that researchers must be aware of and account for in order to obtain meaningful results. Conducting experiments on an isolated population of cells, rather than a heterogeneous mixture of cells, is a common approach to reduce experimental complexity. This allows cell biologists to confidently attribute observed effects and responses to a particular cell type. Thus, mastering the basic techniques of cell isolation is a valuable skill for any cell biologist. Here is everything you need to know about cell separation.