Cardiovascular implants find wide clinical applications, making a great contribution to the treatment of cardiovascular diseases. Although several commercial cardiovascular implants are approved by FDA and millions of patients benefit from these products, there are still not ideal device which can help patients recover completely by the way of a perfect physiological function of the substitutes or a perfect tissue regeneration. In order to overcome unexpected interaction between surface and tissues, surface modification has been introduced for cardiovascular devices to allow independent tailoring of surface and bulk properties. Developing strategies, such as the enrichment of the materials’ surfaces with specific peptides able to contain the inflammatory response while inducing a functional endothelialization, should indicate the promising way for the next generation for vascular repair. Nearly one-fourth of all deaths worldwide are attributable to cardiovascular diseases, including stroke and ischemic heart disease.Vascular and cardio-vascular implants including vascular stents, vascular grafts, polymeric heart valves intervention is necessary to treat cardio-vascular diseases.