Ischemia or ischaemia is a limitation in blood gracefully to tissues, causing a deficiency of oxygen that is required for cell digestion (to keep tissue alive). Ischemia is by and large brought about by issues with veins, with resultant harm to or brokenness of tissue. It likewise implies nearby frailty in a given piece of a body some of the time coming about because of narrowing, (for example, vasoconstriction, apoplexy or embolism). Ischemia contains deficiency of oxygen, yet in addition decreased accessibility of supplements and deficient expulsion of metabolic squanders. Ischemia can be halfway (poor perfusion) or total. Since oxygen is conveyed to tissues in the blood, deficient blood gracefully makes tissue become kept from oxygen. In the profoundly metabolically dynamic tissues of the heart and cerebrum, irreversible harm to tissues can happen in as meager as 3–4 minutes at internal heat level. The kidneys are additionally immediately harmed by loss of blood stream (renal ischemia). Tissues with more slow metabolic rates may experience irreversible harm following 20 minutes. Clinical indications of intense appendage ischemia (which can be summed up as the "six P's") incorporate torment, paleness, pulseless, paresthesia, loss of motion, and poikilothermia. Without prompt intercession, ischemia may advance rapidly to tissue rot and gangrene inside a couple of hours. Loss of motion is an exceptionally late indication of intense blood vessel ischemia and signs the demise of nerves providing the furthest point. Cardiac ischemia open access articles are top journals,  this journal has been successfully publishing quality research articles from many years and looking forward to frame up an eminent, outstanding issue with best quality research articles in this year. We request you to kindly submit and publish your paper in the best journal and get global acknowledgment.