The pieces of sign transduction by interferon-tau (IFN-τ) are widely known during the improvement of ruminants. In trophoblast cells, IFN-τ fuses the incitation of the JAK-STAT pathway, and it can have consequences for other cell types, for example, tumor cells. Here we report that the HPV16-positive BMK-16/myc cell compensated with ovine IFN-τ, understands the foundation of the recognized JAK-STAT and non-conclusive JAK-STAT pathway. The MAPK hailing pathway was instigated, we saw the proteins MEK1, MEK2, Raf1, STAT3, STA4, STAT5 and STAT6. Also, IFN-τ began the declaration of MHC Class I, MX and IP10 in the tumor cells and this reaction might be associated with the viral replication and with the counter proliferative and the immunoregulatory impacts of IFN-τ.