The components of sign transduction by interferon-tau (IFN-τ) are broadly known during the growth of ruminants. In trophoblast cells, IFN-τ includes the actuation of the JAK-STAT pathway, and it can have consequences for other cell types, for example, tumor cells. Here we report that the HPV16-positive BMK-16/myc cell rewarded with ovine IFN-τ, brings about the enactment of the accepted JAK-STAT and non-authoritative JAK-STAT pathway. The MAPK flagging pathway was actuated, we recognized the proteins MEK1, MEK2, Raf1, STAT3, STA4, STAT5 and STAT6. Besides, IFN-τ initiated the declaration of MHC Class I, MX and IP10 in the tumor cells and this reaction might be related with the viral replication and with the counter proliferative and the immunoregulatory impacts of IFN-τ.