Brunner's organ adenoma is an uncommon tumor of the duodenum and may likewise be an unordinary reason for gastrointestinal draining or impediment. The pathogenesis of Brunner organ hamartoma of the duodenum is obscure. We report two instances of Brunner's organ adenoma. Careful resection was completed in light of the fact that the tumor size was enormous in the two cases and one went with dying. The obsessive assessment uncovered submucosal nodular hyperplasia of the Brunner's organs. Brunner's organ adenoma, otherwise called Brunner's hamartoma, is an uncommon duodenal injury that includes not over 5% of kindhearted duodenal tumors. Most of Brunner's organ adenoma is little size masses and numerous patients are asymptomatic. At times, they might be huge in size with clinical appearances of discharge or block. Brunner organ tumor is an uncommon benevolent duodenal sore with an expected frequency of 0.008% dependent on post-mortem examination studies.1 "Adenoma" is in fact a misnomer, in light of the fact that the mass is certainly not a genuine neoplasm but instead, a hamartomatous or hyperplastic assortment of developing organs with no known potential for dangerous transformation.2 The tumor, for the most part, begins from the back mass of the first or second duodenal portion, reflecting the dissemination of the Brunner organs, whose basic mucin emissions shield the epithelium from gastric chyme. The pathogenesis is obscure; essential dysembryoplasia or an overstated compensatory reaction tohyperchlorhydria, pancreatic deficiency, or H pylori disease have been hypothesized as potential mechanisms.3 It is ordinarily found by chance on endoscopy. At the point when suggestive, the most widely recognized introductions are drain or gastric outlet deterrent, yet pancreatitis, intussusception, and loose bowels have likewise been reported.1, 4 Treatment is endoscopic or careful evacuation. There are no settled rules for follow-up.5 At 10 months; the patient is doing great with an unremarkable stretch endoscopy, standardized hemoglobin, and no indications of dying. Brunner's organ adenomas are top diaries. Brunner's organ adenoma is an incredibly uncommon benevolent little inside neoplasm, regularly found by chance during upper gastrointestinal endoscopy or radiological diagnostics and it has been effectively distributing quality research articles from numerous years and anticipating outline up a famous, extraordinary issue with best quality research articles in this year. We demand you to mercifully submit and distribute your paper in the best diary and get worldwide affirmation. Brunner’s gland adenomas are top journals. Brunner's gland adenoma is an extremely rare benign small bowel neoplasm, often discovered incidentally during upper gastrointestinal endoscopy or radiological diagnostics and it has been successfully publishing quality research articles from many years and looking forward to framing up an eminent, outstanding issue with best quality research articles in this year. We request you to kindly submit and publish your paper in the best journal and get global acknowledgment.