Early studies of high-dose chemotherapy (HDC) for breast cancer were inhibited by diminutive numbers and the lack of adequate control groups. The French PEGASE Group was founded to perform more immensely colossal and felicitously randomized comparative studies of this approach. An estimated 1 million cases of breast cancer are diagnosed annually ecumenical. Of these, more than 170,000 are described as triple-negative. Triple-negative breast cancer (TNBC) is defined by the lack of protein expression of estrogen receptor (ER) and progesterone receptor (PR) and the absence of HER2 protein overexpression. Early results suggest that the replication rate can be incremented in patients with estrogen and/or progesterone-positive receptors. It is eminent that in a study conducted on postmenopausal women resistant to cytotoxic and/or hormonal drugs, the median duration of survival was 13.5 months, while CRs plus PRs did not reach the median at 24 months after starting MPA treatment. High dose MPA is essentially devoid of major side effects. Mitigation of pain, increment in appetite and body weight, and sense of well being are characteristic features of the ameliorated quality of life under MPA treatment. However, a gluteal abscess (from 2% to 20% dose cognate) is the most frequent side effect. The impact of the journal is influenced by impact factor, the journals with high impact factor are considered more important than those with lower ones. Indexing provides easy access of the article online. The international journals are among the best open access journals in the world, set out to publish the most comprehensive, relevant and reliable information based on the current research and development on a variety of subjects. This information can be published in our peer reviewed journal with impact factors and are calculated using citations not only from research articles but also review articles (which tend to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports. The inclusion of these publications provides the opportunity for editors and publishers to manipulate the ratio used to calculate the impact factor and try to increase their number rapidly. Impact factor plays a major role for the particular journal.