Before transfusion is started, consent should be obtained, and the patient’s wristband, blood unit label, and compatibility test report must be checked at the bedside to ensure that the blood component is the one intended for the recipient. Use of an 18-gauge (or larger) needle prevents mechanical damage to and hemolysis of red blood cells. A standard filter should always be used for infusion of any blood component. Only 0.9% saline IV should be allowed into the blood bag or in the same tubing with blood. Hypotonic solutions lyse red blood cells, and the calcium in Ringer’s lactate can cause clotting. Transfusion of 1 unit of blood or blood component should be completed by 4 hours; longer duration increases the risk of bacterial growth. If transfusion must be given slowly because of heart failure or hypervolemia, units may be divided into smaller aliquots in the blood bank. For children, 1 unit of blood can be provided in small sterile aliquots used over several days, thereby minimizing exposure to multiple donors.