BioSystems encourages experimental, computational, and theoretical articles that link biology, evolutionary thinking, and the information processing sciences. The link areas form a circle that encompasses the fundamental nature of biological information processing, computational modeling of complex biological systems, evolutionary models of computation, the application of biological principles to the design of novel computing systems, and the use of biomolecular materials to synthesize artificial systems that capture essential principles of natural biological information processing. Although their proportion in the research market (e.g. expression profiling) has increased significantly they still play a minor role in clinical and medical diagnostic fields. Main drawbacks for the implementation of BioChips in clinical routine analysis are insufficient reproducibility, lack of standardization as well as expensive chips and detectors. With respect to BioChip production, industrial standards and uniform protocols have not yet been defined. Therefore different BioChip layouts and analytical performance cannot be compared.