The Journal publish high-quality original research that advances knowledge on these topics generalizable to other settings and countries and from other disciplines related to medicine, including nursing, practice management, professions allied to medicine and social science. This journal offers strong editorial content and cutting-edge views along side peer-reviewed clinical articles, original research, and continuing professional development articles to tell practice and improve nursing skills. Bioreactor systems are an important component within the process of 3D tissue engineering and therefore the formation of tissue constructs. Bioreactors are wont to provide a tissue-specific physiological in vitro environment during tissue maturation. Based on the bioreactor technology, various tissue systems are often incubated in vitro. In this chapter, there's a radical review of the various sorts of bioreactor applications that are used during the tissue-engineering process. It demonstrates the essential principles and requirements for bioreactor development. By using computation fluid dynamics, the flow with the system was optimized.