Bioprocesses have cut off as a significant way to help endurance and satisfy various requirements for a huge number of years in the mankind's history. Early bioprocesses (ca. 4000 BC) utilized characteristic microorganisms, for example, yeasts and parasites, to create various items, including bread, lager, and cheddar. The principal sanitization step was ethanol refining did around 2000 BC. With propels in science and building, bioprocesses increments in both creation scale and unpredictability with coordinated preparing steps. Not with standing nature microorganisms, present day bioprocesses additionally utilize different specialists, for example proteins and cells from plants, bugs, and creatures, to deliver different items, including natural acids, anti-toxins, and helpful mixes. Bioprocesses are created by consolidating diverse essential advances (or âunit operationsâ, presented by Arthur D. Little in 1915, for example, aging, filtration and drying. For quite a long time, scaling up from a benchtop framework by means of a pilot plant to an all out manufacturing plant has been the standard act of the advancement of mechanical scale bioprocesses. In any case, it is confronted with difficulties from the more rigid necessities, for example, size and cost decreases in hardware, lower vitality utilization and waste emanation, and a more secure activity condition, because of the new pattern of utilizing maintainable creation conspires in bioprocesses. To address these difficulties, a methodology called âprocess intensificationâ has been utilized to improve bioprocesses. It centers around growing new hardware and techniques that prompts more savvy and reasonable bioprocesses. Since its introduction in the 90's , microfluidics has gained critical ground through the accumulating research results. It has discovered numerous organic applications, for example, quality/protein control and examination, cell-based frameworks, biosensors, and sedate disclosure and conveyance. Microfluidic gadgets have as of late come into consideration as a useful asset for bioprocess escalation on account of their low manufacture expenses and reagent utilization, little structure factors for safe activity in a controlled situation, and ability of coordinate different fundamental advances onto one chip. A great deal of work has been coordinated to the advancement of microreactors for enzymatic responses (for example hydrolysis, esterification, oxidation/decrease, and polymerization). For downstream handling, microfluidic gadgets have been utilized to create frameworks for division of cells and cleaning of helpful mixes. The outcomes so far are promising for scaled down bioprocesses. More data on the scaling down of bioprocesses can be found in the writing.