Brain stroke is a surprising severe infection resulting from a burst or blockade of blood vessels inside the brain and one of the fundamental causes of incapacity a few of the aged. More than 15 million humans go through stroke every yr, 5 million die and another 5 million are disabled completely, in keeping with the World Health Organization. As the world’s populace is getting old, it's miles crucial to save you sicknesses consisting of mind stroke which can severely reduce the Quality of Life (QOL) of the aged. For the prevention of brain stroke, it's far critical to understand the chance of ailment onset.It is concept that reactive oxygen species (ROS), along with superoxide anion (O2-), hydrogen peroxide (H2O2) and hydroxyl radical (•OH), are prominently involved in mobile harm inclusive of mind infarction [1,2]. However, we found that acrolein (CH2=CH-CHO), specially produced from spermine [NH2(CH2)3NH(CH2)4NH(CH2)3NH2], an essential element of cellular growth and viability [3-5], is more strongly concerned in cellular damage at some point of brain infarction via its conjugation with proteins [6,7]. The length of mind infarction become nearly parallel with the expanded fee of PC-Acro (proteinconjugated acrolein) and acrolein-producing enzymes, i.E. Spermine oxidase and acetylpolyamine oxidase in plasma [8]. Consequently, we could pick out silent brain infarction, i.E. Small mind infarction, with eighty four% sensitivity and specificity by means of measuring PC-Acro, IL-6 and CRP in plasma together with age and through calculating the RRVBI with synthetic neural networks [9] the use of NEUROSIM/L software