Biological Chemistry is a scientific discipline spanning the fields of chemistry and biology. The discipline involves the application of chemical techniques, analysis, and often diminutive molecules engendered through synthetic chemistry, to the study and manipulation of biological systems. In contrast to biochemistry, which involves the study of the chemistry of biomolecules and regulation of biochemical pathways within and between cells, chemical biology deals with chemistry applied to biology (synthesis of biomolecules, simulation of biological systems etc. Chemical biologists work to ameliorate proteomics through the development of enrichment strategies, chemical affinity tags, and incipient probes. Samples for proteomics often contain many peptide sequences and the sequence of interest may be highly represented or of low abundance, which engenders a barrier for their detection. Chemical biology methods can abbreviate sample involution by selective enrichment utilizing affinity chromatography. This involves targeting a peptide with a distinguishing feature like a biotin label or a post translational modification. Methods have been developed that include the utilization of antibodies, lectins to capture glycoproteins, and immobilized metal ions to capture phosphorylated peptides and enzyme substrates to capture cull enzymes. To increment the overtness and facilitate of avail of open access scientific and scholarly journals top online publishing journals are indexed in different indexing and archiving accommodations. Indexing provides facile access of the article online. The top online publishing journals publish articles which are cited as references by many authors in their work. Citations are paramount for a journal to get impact factor. Impact factor is a quantification reflecting the average number of citations to recent articles published in the journal. The impact of the journal is influenced by impact factor, the journals with high impact factor are considered more consequential than those with lower ones. Indexing provides facile access of the article online. The international journals are among the best open access journals in the world, set out to publish the most comprehensive, pertinent and reliable information predicated on the current research and development on a variety of subjects. This information can be published in our peer reviewed journal with impact factors and are calculated utilizing citations not only from research articles but additionally review articles (which incline to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports. The inclusion of these publications provides the opportunity for editors and publishers to manipulate the ratio used to calculate the impact factor and endeavor to increment their number expeditiously. Impact factor plays a major role for the particular journal. Earth Science Journal works to Publish most reliable and Consummate source of information regarding advance revelations and development