Bioengineering is the application of the life sciences, physical sciences, mathematics and engineering principles to define and solve problems in biology, medicine, health care and other fields. Biological engineering, or bioengineering/bio-engineering, is the application of principles of biology and the tools of engineering to create usable, tangible, economically viable products. Biomedical engineering, or bioengineering, is the application of engineering principles to the fields of biology and health care. Bioengineers work with doctors, therapists and researchers to develop systems, equipment and devices in order to solve clinical problems. Examples of bioengineering research include bacteria engineered to produce chemicals, new medical imaging technology, portable and rapid disease diagnostic devices, prosthetics, biopharmaceuticals, and tissue-engineered organs. Considered by Forbes as a high paying little-regarded career, Biomedical engineering is a multidisciplinary STEM that involves biology and engineering and utilizes engineering principles in medical services and general health care provision. It is a relatively virgin fertile career exhibiting a niche worldwide.