. Biotransformation is the synthetic alteration (or adjustments) made by a life form on a substance compound. In the event that this adjustment finishes in mineral mixes like CO2, NH4+, or H2O, the biotransformation is called mineralization.  Biotransformation implies concoction adjustment of synthetic compounds, for example, supplements, amino acids, poisons, and medications in the body. It is likewise expected to render non-polar mixes polar with the goal that they are not reabsorbed in renal tubules and are discharged. Biotransformation of xenobiotics can overwhelm toxicokinetics and the metabolites may arrive at higher fixations in living beings than their parent compounds. Recently its application is viewed as a proficient, financially savvy, and effectively material methodology for the valorization of agrarian squanders with possibilities of upgrading existing bioactive parts and union of new compound.  Biotransformation of different toxins is a supportable method to tidy up tainted environments. These bioremediation and biotransformation strategies saddle the normally happening, microbial catabolic decent variety to debase, change or gather a gigantic scope of mixes including hydrocarbons (for example oil), polychlorinated biphenyls (PCBs), polyaromatic hydrocarbons (PAHs), pharmaceutical substances, radionuclides and metals. Major methodological discoveries as of late have empowered definite genomic, metagenomic, proteomic, bioinformatic, and other high-throughput investigations of ecologically pertinent microorganisms giving extraordinary bits of knowledge into biotransformation and biodegradative pathways and the capacity of living beings to adjust to changing natural conditions.  Natural procedures assume a significant job in the expulsion of contaminants and toxins from the earth. A few microorganisms have surprising catabolic flexibility to corrupt or change such mixes. New methodological achievements in sequencing, genomics, proteomics, bioinformatics, and imaging are creating huge measures of data. In the field of Environmental Microbiology, genome-based worldwide examinations open another period giving phenomenal in silico perspectives on metabolic and administrative systems, just as hints to the development of biochemical pathways pertinent to biotransformation and to the atomic adjustment procedures to changing natural conditions.  Best review articles in biotransformation are top open access journals, and this journal has been successfully publishing quality research articles from many years and looking forward to frame up an eminent, outstanding issue with best quality research articles in this year. We request you to kindly submit and publish your paper in the best journal and get global acknowledgment.