The journal focuses on all fields of drug style as well as drug discovery, drug style by rational approach, target-based style, drug synthesis, drug metabolism, structure-based drug style, molecular modeling, ligand-based interaction, development of the drug, in silico chemoinformatics and bioinformatics technologies, receptor agonist/antagonist, peptidase substrate/inhibitor, peptidomimetic. Molecular moorage has become Associate in Nursing progressively vital tool for drug discovery. during this review, we have a tendency to gift a quick introduction of the offered molecular moorage ways, and their development and applications in drug discovery. The relevant basic theories, as well as sampling algorithms and evaluation functions, area unit summarized. The variations in and performance of accessible moorage software system also are mentioned. Molecular moorage has been the foremost wide utilized technique. tho' the most application lies in structure-based virtual screening for identification of recent active compounds towards a selected target supermolecule, during which it's created variety of success stories, it's really not a complete technique however is often embedded in an exceedingly advancement of various in silico likewise as experimental techniques.