Atrial natriuretic peptide (ANP) or atrial natriuretic issue (ANF) is a natriuretic peptide hormone secreted from the cardiac atria that during human beings is encoded by the NPPA gene. Natriuretic peptides (ANP, BNP, and CNP) are a own family of hormone/paracrine elements that are structurally related. the principle feature of ANP is causing a reduction in accelerated extracellular fluid (ECF) quantity by using increasing renal sodium excretion. ANP is synthesized and secreted with the aid of cardiac muscle cells in the partitions of the atria within the heart. these cells contain quantity receptors which respond to extended stretching of the atrial wall due to expanded atrial blood quantity.reduction of blood volume through ANP can bring about secondary results consisting of reduction of extracellular fluid (ECF) volume (edema), advanced cardiac ejection fraction with resultant improved organ perfusion, reduced blood pressure, and elevated serum potassium. those outcomes may be blunted or negated by numerous counter-regulatory mechanisms operating simultaneously on each of those secondary consequences.receptors as ANP does, however with 10-fold lower affinity than ANP. The organic 1/2-life of BNP, but, is twice as long as that of ANP, and that of NT-proBNP is even longer, making these peptides better choices than ANP for diagnostic blood trying out..