The Astrophysics current missions include three of the Great Observatories originally planned in the 1980s and launched over the past 28 years. The current suite of operational Great Observatories include the Hubble Space Telescope, the Chandra X-ray Observatory, and the Spitzer Space Telescope. Additionally, the Fermi Gamma-ray Space Telescope explores the high-energy end of the spectrum. Innovative Explorer missions, such as the Neil Gehrels Swift Observatory, NuSTAR, TESS, as well as Mission of Opportunity NICER, complement the Astrophysics strategic missions. SOFIA, an airborne observatory for infrared astronomy, is in its operational phase. All of the missions together account for much of humanity's accumulated knowledge of the heavens. Many of these missions have achieved their prime science goals, but continue to produce spectacular results in their extended operations.