Aquaculture is one of the fastest growing forms of food production in the world and the fastest growing sector in the livestock industry. In a $140 billion market, startups in seafood and aquaculture technology raised $193 million in 2016, which marked a 271% increase from the two years prior combined. Disease prevention is a critical aspect of aquaculture. Changing ocean temperatures and water quality make animals and plants more stressed and susceptible to disease, yet innovation is lacking in prevention compared to land-based agriculture. Terrestrial food animal farmers can easily deploy dozens of vaccines and preventive solutions, while aquaculture has less choice and significant delivery challenges (more on this below). Vaccines are still administered by hand, and there simply aren’t good preventive measures for many infestations. Sea lice infestation, for example, is common and devastating in farmed salmon. While migratory salmon shed sea lice when they reach freshwater, farmed salmon are contained in saltwater, and the parasites proliferate resulting in physical damage and subsequent exposure to bacterial pathogens. Historical and existing scaled solutions have undesirable consequences. For example, hydrogen peroxide stresses the salmon. Adding a lice-killing benzoate to feed leaves toxic waste in the environment and lice are becoming resistant to the treatment, requiring higher doses. Freshwater or heated water “dips” create added stress. There are few emerging opportunities for sustainable innovation for the massive problem of sea lice. These include using “cleaner fish” like Ballan wrasse to graze on sea lice in aquaculture pens, physical barriers or “skirts” and feed supplements to boost natural defenses to infection. Clearly, this is an area desperate for effective, scalable and effective innovation.