Apoptosis is an international peer-reviewed journal devoted to the rapid publication of innovative basic and clinically-oriented investigations into programmed cell death. It aims to stimulate research on the basis of mechanisms of apoptosis and on its role in various human disease processes including: cancer, autoimmune disease, viral infection, AIDS, cardiovascular disease, neurodegenerative disorders, osteoporosis and ageing. The editors intend to encourage the development of clinical therapies against apoptosis-related diseases.

Stimulates research on the basis of mechanisms of apoptosis and on its role in various human disease processes

Investigates links to cancer, autoimmune disease, viral infection, AIDS, cardiovascular disease, neurodegenerative disorders, osteoporosis and ageing

Encourages development of clinical therapies against apoptosis-related diseases

90% of authors who answered a survey reported that they would definitely publish or probably publish in the journal again

Death of the cells in multicellular organisms to regulate the number of cells by programmed cell death is called as apoptosis. In this process caspases proteins breaks the cellular components , which leads to release of DNases which destroys the cellular DNA which leads to death of the cell. The top open access journals are peer reviewed scholarly journals of hydrology. The top open access journals are freely available on the public internet domain, allowing any end users to read, download, copy, distribute, prink, search or link to the full texts of the articles. These provide high quality, meticulously reviewed and rapid publication, to cater the insistent need of scientific community. These journals are indexed with all their citations noted.

 

In multicellular life forms, cells that are no more required or are a danger to the living being are regulated by a hard controlled cell suicide procedure known as apoptosis.Apotosis is one of the central point leading to failure of human islet Transplanatation. The present hypothesis of cell apoptosis recommends two noteworthy pathways. Cell death by apoptosis is hereditarily controlled. Apoptosis is a piece of typical improvement and upkeep of testicular . A sufficient measure of germ cells are dispensed with through the procedure of apoptosis keeping in mind the end goal to keep up an exact germ cell population in agreeability with the strong limit of cells.Apoptosis is a modified and controlled method of cell death. Variations from the norm in control of modified cell death (apoptosis) assume a discriminating part in tumourigenesis. Inhibitors of customized cell passing defiantly draw out cell practicality so adding to event and development of tumors.

The cell cycle checkpoints stringently direct every period of cycle before the completion of entire methodology. Initiation of these checkpoints prompts cell spin capture through balance of CDK movement which in this way permits the cells to repair a large portion of their deformities before their transmission to the subsequent little girl cells. If there should be an occurrence of intemperate DNA harm or hereditary absconds in the repair apparatus, cells either enter the senescence or experience apoptosis .In the first pathway, cells deliver genius apoptotic proteins in light of outside boosts, for example, mitochondria poisons and DNA harm. The expert apoptotic proteins enact cytochrome C discharge from the mitochondria, which then activate caspase 9 and caspase-3, promoting cell apoptosis . (TNF-α), and interferon-γ (IFN-γ) . One wonderful highlight of B-Cell Lymphoma 2 relatives is that they differentially associate with one another to control apoptosis. Adjusting the capacity of cells to experience apoptosis is a key approach in the improvement of treatments for some sicknesses, including tumor.

Last Updated on: Nov 27, 2024