The antineoplastic operators or anticancer drugs speak to a expansive and different lesson of medicines. They by and large have constrained but imperative employments, and frequently have noteworthy hepatotoxicity. A few antineoplastic operators can moreover cause peculiar liver harm due to immunologic or metabolic characteristic. Hence, ordinary medicate actuated cholestatic liver harm can happen in uncommon occurrences after treatment with cyclosphosphamide, azathioprine, mercaptopurine, melphalan and temozolomide. Intense hepatocellular harm can happen with flutamide, bicalutamide and thalidomide. Steatohepatitis can happen with L-asparaginase, methotrexate and tamoxifen Chosen anticancer operators have too been connected to immunoallergic hepatitis or to immune system hepatitis-like harm.