Blood Disorders & Transfusion Journal is a peer reviewed and open access journal aimed to publish most interesting and complete reliable source of information on current development and advanced research findings in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide. Blood Disorders & Transfusion journal with highest impact factor offers an open access platform to the authors to publish their research outcome.

Anti-HBc IgG and IgM antibodies are the body’s first response to a hepatitis B virus (HBV) infection. These antibodies are directed against a portion of the HBV called “core”. Anti-HBc IgG and IgM appear shortly after the symptoms and onset of measurable virus surface antigen (HBsAg). IgM arrive first and are then replaced by IgG. Total Anti-HBc (IgG plus IgM) are interpreted in light of clinical factors and the results of other hepatitis B markers, particularly HBsAg and anti-HBs.

A negative total anti-HBc result may indicate the absence of a recent or previous HBV infection (negative HBsAg and anti-HBs). However, a developing infection cannot be ruled out. The combination of negative total anti-HBc and HBsAg results, but positive anti-HBs results indicates an individual that has been vaccinated against hepatitis B. In combination with positive HBsAg/negative anti-HBs, a negative total anti-HBc test may indicate an individual in the acute phase of the disease or a reactivation of the virus in a chronic carrier.