Tuberculosis (TB) is caused by mycobacterium. though TB could be a curable sickness, it continues tobe one in every of the foremost necessary infectious causes of death worldwide. country ranks third on the list of TB highburden countries within the world with eighty six, cases deaths and also the Multi Drug Resistant T.B. (MDR TB)estimated cases in country is ten. This analysis was aimed to isolate and characterize of sentimental coral Sinularia sp.-associated bacterium having medicine activity against T.B. bacterium. There were109 isolates collected from Sinularia sp. 2 isolates from Sinularia sp.-associated bacterium, SC4TGZ3 andSC4TGZ4 were with success screened for medicine against T.B. bacterium. SC4TGZ3 was found toinhibit the expansion of MDR TB strain HE, MDR TB strain SR and H37Rv. Whereas, SC4TGZ4 was found toinhibit the expansion of MDR TB strain HE. supported PCR amplification 16S rDNA softcoral bacateria wereidentified as follows: SC4TGZ3 was closely associated with Pseudovibrio sp. and SC4TGZ4 was closely connected to Alpha proteobacterium sp.