103 Anastomotic leaks are defined as ‘a leak of luminal contents from a surgical join‘. They are the most important complication to recognise following gastrointestinal surgery.  Early diagnosis, resuscitation and treatment of an anastomotic leak is key. Delay leads to prolonged contamination of the abdomen or chest by the luminal contents, leading to the development of severe sepsis and progression to multi organ failure and death. It is important to remember that any patient who is not progressing as expected or who deteriorates after surgery should be considered to have an anastomotic leak until proven otherwise. Anastomotic leakage was defined as any clinical signs of leakage, confirmed by radiological examination, endoscopy, clinical examination of the anastomosis (i.e., palpation of the anastomosis), or reoperation. The leakages were graded retrospectively according to the system proposed by Rahbari et al. . Anastomosis takedown was defined as an interruption of the continuity of the bowel and the formation of a stoma. The blood loss was the volume noted by the anesthetic nurse during surgery. The surgical approach was divided into three groups: laparoscopy, laparotomy, and conversions from laparoscopy to open surgery, but in statistical calculations, the converted group is in the laparoscopic group as intention to treat. Anastomosis not taken down, salvage was defined as preservation of the bowel continuity with repair of the anastomosis or conservative treatment with or without drainage or antibiotics. Death was recorded within 30 and 90 days from index surgery. Time to diagnosis of a leakage was calculated as days between the index operation and diagnosis of the leakage with reoperation or CT abdomen or CT rectal contrast or with endoscopy or when fecal containing fluid was seen in the drainages. Total hospital stay included a second admission to hospital if the cause was anastomotic leakage or complications thereof. A stoma was counted as permanent if it was present at the end of follow-up time. Anastomotic leaks are characterized as 'a break of luminal substance from a careful join'. They are the most significant complexity to perceive following gastrointestinal medical procedure. Early analysis, revival and treatment of an anastomotic hole is vital. anastomotic-leak-review-articles has been successfully publishing quality research articles from many years and looking forward to frame up an eminent, outstanding issue with best quality research articles in this year. We request you to kindly submit and publish your paper in the best journal and get global acknowledgement.