Human Computer Interaction (HCI) or Human Factors studies in MIS are concerned with the way’s humans interact with information, technologies, and tasks, especially in business, managerial, organizational, and cultural contexts. This article describes the existence and importance of HCI research in the MIS discipline, its historical development, some of its characteristics, publication opportunities, and future research directions. It is believed that HCI is the subject of a strong research stream in MIS, and will continue to be strong in the foreseeable future. It is hoped that HCI studies can provide the evolution of the human centered technology development that enhances our work/job, our various needs, our organizations, our societies, and ourselves