In this investigation, the relationship between the intense poisonousness of 15 mixes to Daphnia magna, communicated as 24-and 48-h LC50 values, and the comparing oral LD50 values for the rodent was tried. Since there was proof of a solid connection between the two species, the example was stretched out to 54 cases by including the qualities for intense poisonousness to D. magna and rodent of more synthetic compounds distributed by different creators. In this way, a sum of 54 information focuses were additionally used to determine the connection between the intense harmfulness of concoction mixes to D. magna and that to the rodent. To sum up its legitimacy, the D. magna test is more explicit than delicate as a marker of poisonousness to the rodent. At the point when it is utilized with a synthetic that has a high likelihood of being harmful to D. magna (LC50< 0.22 mg/L), the test gives significant data on the off chance that it is sure, basically giving proof of harmfulness to the rodent (with a likelihood of 0.83). Then again, a negative test (D. magna LC50>0.22 mg/L) has a likelihood of effectively allocating nontoxicity to the rodent equivalent to 0.74. This examination and results distributed by different creators give great proof of the materialness of utilizing invertebrate tests as prescreening strategies, accordingly extensively decreasing the quantity of warm blooded creatures required in poisonousness testing.